Celiac disease is a genetic disease. It means particular genes are responsible for celiac disease. Doctors use genetic testing for celiac disease to identify the chances to develop it. The goals of testing are celiac disease diagnosis, monitoring, and screening.
This test to diagnose celiac disease searches for genes named HLA DQ2 as well as DQ8. A person with this disease must possesses either one or both genes. But at the same time if you have one or both genes do not indicate you suffer from this disease. But it means it may develop. It is unlikely that someone with no gene variations will develop celiac disease. Taking the HLA dq2/dq8 testing in UK will help you determine your status.
Here we will discuss celiac disease genetic testing, why to do it, and the results of the test.
What Exactly Is Celiac Disease?
Celiac disease is the autoimmune condition. This disease causes damage to the small intestine caused by WBC. Symptoms of celiac disease include diarrhea, growth problems, anemia, bloating and gas. Gluten is one type of protein which causes celiac disease.
The inheritance of genes is the cause of celiac disease. Celiac illness can thus run in families. You are more likely to get celiac disease if you have a close family member, parent, or sibling who has it.
Celiac Disease Genes
Celiac disease genes are parts of human leukocyte antigens (HLA). They are called DQ genes. Each one of us has two sets of DQ genes, one from father and another from mother. Out of various kinds of DQ genes few cause celiac disease.
● HLA-DQ2
● HLA-DQ7
● HLA-DQ8
HLA-DQ2
This gene is a commonly found celiac gene. It is usually found in majority of human beings. Approximately 95% of celiac patients have HLA-DQ2.
HLA-DQ8
Most frequently, autoimmune illnesses like celiac disease are associated with HLA-DQ8. This gene has the mysterious ability to guide the immune system to target and kill its cells. This will turn the body’s defenses against itself.
According to research, having the HLA-DQ8 increases your risk of developing celiac disease. Approximately 2.5 to 5% of patients with celiac disease have HLA-DQ8.
HLA-DQ7
Some people get celiac disease even if they don’t have HLA-DQ2 or HLA-DQ8. If HLA dq2 and dq8 blood test results are negative then one can test for HLA-DQ7.
HLA-DQ7 gene is not one of the major genes that is responsible for celiac disease.
Test for Celiac Disease
The doctor should examine you if he suspects celiac disease. It is also necessary to look at your medical history. Your doctor might also additionally order a biopsy. In this procedure a small sample of cells is examined from your small intestine.
The doctors may use the HLA dq2 and dq8 blood tests or mouth swab samples for celiac genetic tests.
Importance of carrying out a celiac disease test
One set of DQ8 or DQ2 has potential to develop a celiac disease to you. Considering that you get one set of this gene in heredity from your parents. It’s likewise possible for a person to possess two sets of any of these genes. Having two sets of any of these genes may possibly raise your risk high. The identification of such genes in you will help you determine your risk.
Doctor may ask for a genetic test that helps him to find out whether you have this disease or not. Our HLA dq2 and dq8 testing costs are affordable. So don’t hesitate to contact us for testing.
Celiac Gene Diagnosis Process
Many celiac disease patients are unaware of their condition. Before going with a gluten-free diet, it’s crucial to get tested for celiac disease. Your HLA dq2 and dq8 blood test results may look normal if you stop eating gluten.
For testing you need to provide either:
● Saliva in a vial or syringe
● few of the cells inside your cheek by swab
● blood sample
Your doctor will then examine the sample in the lab. These all techniques give accurate results.
A negative gene test rules out the potential of acquiring celiac disease in the future. So family members may find this information useful. We suggest testing all family members for celiac disease genetically, especially young children.
Celiac testing cost
Your insurance company may not pay the HLA dq2 and dq8 testing costs. The total prices are $150 to $200. This price includes the test order, lab fees, and a digital copy of the results. The testing price depends on the test you will take.
Understand Your Test Results
The lead time of tests result ranges from some to some weeks depends on the labs. Having this gene doesn’t confirm the person has a celiac disease. Even if you are tested positive to this genetic test, it may be possible that you are not celiac disease patient.
In case you feel such kind of symptoms, genetic test is helpful to diagnose the disease. Sometimes celiac test results are not enough to identify the disease. In this situation a gene test can be helpful to diagnose or rule out this disease.
Your doctor could suggest a genetic test for you, if any of your family members have the disease. This can assist in rule out this illness or warn you of any potential predispositions you may have.
Polite advice by Private Blood Tests London Team
Celiac disease is caused due to two main genes DQ8 and DQ2. Genetic test will diagnose if you have either or both of them. Genetic testing will not confirm whether you are suffering from celiac disease or not. It predicts your chances. Visiting HLA dq2 and dq8 blood tests in the UK will help you determine your status.
You should consult specialist if you experience celiac disease symptoms. Genetic testing will help your specialist to execute the treatment of this disease.
